ADISO PORTFOLIO
Multimodal activity contributes to efficacy while local targeting diminishes risk of off-target effects including immunosuppression
Our Pipeline
Small Molecule Modulator of Neutrophil Trafficking and Activation
Discovery
IND Enabling
Phase 1
Phase 2
Phase 3
ADS051
Ulcerative Colitis
ADS051 is an oral, gut-restricted, small molecule modulator of neutrophil trafficking and activation for the treatment of ulcerative colitis. ADS051 blocks MRP2-mediated neutrophil trafficking into and FRP1-mediated neutrophil activation within the colonic lumen. Unlike currently available therapies, this addresses neutrophil-mediated tissue damage, a hallmark of UC pathology. In a healthy volunteer study, ADS051 was safe and well-tolerated and restricted to the gut with limited systemic exposure.
First-In-Class Small Molecule Inhibitor of the NLRP1 and 3 Inflammasomes
Discovery
IND Enabling
Phase 1
Phase 2
Phase 3
ADS032
Respiratory Inflammation
ADS032 is a novel small molecule inhibitor that blocks two types of inflammasomes simultaneously, NLRP1 and NLRP3 – the innate immune system’s receptors and first line sensors of pathogens and other danger signals. Chronic activation of NLRP1 and NLPR3 is directly implicated in a wide
range of inflammation-triggered conditions across multiple organ systems. By targeting both NLRP3 and NLRP1, ADS032 may provide a comprehensive anti-inflammatory approach across a range of diseases.
Single Strain Live Biotherapeutic Product (SS-LBP) Platform
Discovery
IND Enabling
Phase 1
Phase 2
Phase 3
ADS024 CDI
Prevention of CDI Recurrence
ADS024 is an oral single strain live biotherapeutic product (SS-LBP). A naturally occurring live biotherapeutic product, ADS024 possesses a dual mechanism of action. It is bactericidal toward Clostridioides difficile and degrades Toxins A and B produced by C. difficile while maintaining other components of the microbiome. ADS024 is a single strain multimodal LBP and is manufactured from a pure, clonal bacterial cell bank, yielding a standardized lyophilized drug product eliminating the need to directly source from donor fecal material.
ADS024 UC
Ulcerative Colitis
ADS024 is an oral single strain live biotherapeutic product (SS-LBP). A naturally occurring live biotherapeutic product, ADS024 modulates inflammation as a single strain multimodal LBP and has been shown to reduce neutrophil trafficking through the colonic epithelium. ADS024 is manufactured from a pure, clonal bacterial cell bank, yielding a standardized lyophilized drug product eliminating the need to directly source from donor fecal material.